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Clindamycin hydrochloride and Clindamycin phosphate ester

Number of visits:1049 Date:2015/12/22 9:04:53

Clindamycin hydrochloride and clindamycin phosphate ester have some differences.

Clindamycin hydrochloride is clindamycin hydrochloride, clindamycin phosphate was found after the clindamycin phosphate  esterification. Both groups are clindamycin effectively. After entering the body, clindamycin hydrochloride can directly produce effect, while clindamycin phosphate ester hydrolysis releases can result in the efficacy of clindamycin.Adding phosphate cancontrol the pharmacological activities and reduce adverse reactions. Clindamycin phosphate is decomposed into clindamycin can enter human body after to efficacy, but the effects of the clindamycin phosphate is many times of clindamycin, may be associated with parts in the body break down.Like some drugs instead of fat soluble preparation curative effect after multiplying principle is the same.

Clindamycin phosphate gel was used in the treatment of acne vulgaris, clindamycin phosphate gel with restrain acne propionic acid bacillus, grain propionic acid bacillus, the growth of staphylococcus aureus and epidermis staphylococcus, etc.Clindamycin phosphate gel was absorbed by hydrolysis ChengKeLin play a role of antimicrobial, the acne propionic acid bacillus has good antibacterial activity. Clindamycin phosphate gel can reduce fatty acids on the surface of the skin, which is beneficial to the treatment of acne.

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