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Clindamycin hydrochloride can treat chronic periodontitis

Number of visits:1020 Date:2015/12/21 8:00:47

Periodontitis is dental common disease, frequently-occurring disease. It was mainly used for anaerobic bacteria in the mixed infection of chronic inflammatory diseases.Under the gum plaque are the risk factors influencing the occurrence and development of periodontitis.
We use the clindamycin hydrochloride oral treatment of chronic periodontitis, trying to improve clinical curative effect, reduce drug varieties, the purpose of reducing side effects.

Clindamycin hydrochloride is a broad-spectrum antimicrobial agents, it is already the chloride ion replace lincomycin molecules in the 7th of the hydroxyl of semisynthetic derivatives.
Mechanism and big ring same lipid antibiotics, can the irreversible combined to the bacterial ribosomal 50s subunits by inhibiting protein synthesis inhibition of bacteria with the extension of the peptide chain, thereby eliminating bacteria on the surface of A protein and fluffy coat, make them susceptible to devour and destroy.
Also have enhanced the immune adjustment function of the body's immune system, enhance karyotype leukocyte phagocytosis and bactericidal function, change the bacteria on the surface of the activity and inhibition of bacterial toxins.Its main characteristic is to each kind of anaerobic bacteria has strong sterilization effect, is a significant activity to G + bacterium.
Clindamycin hydrochloride oral can be fully absorbed, the combination of the plasma protein rate is as high as 90%, most can be distributed throughout the body tissue and body fluids.
Study found that gum porphyrin, middle plate bacteria bacterium, forsyth steiner bacteria, teeth tartar treponema, four kinds of anaerobic bacteria to clindamycin, minocycline for high, moderate and sensitive.Clarithromycin, luo erythromycin bacteriostatic effect is good, metronidazole, for indications of porphyrin gums sensitive bacterium, is not sensitive to the other.
Thus the clindamycin wide antimicrobial spectrum, strong antibacterial activity, high peak concentrations of gingival sulcus liquid, maintain a long time, less side effects, etc.
In the clinical use of clindamycin alone treatment of periodontitis can also decrease the gingival index and gingival sulcus bleeding index, the clinical symptoms improved and ease. So in the clinical use of clindamycin hydrochloride alone can improve the clinical efficacy of treatment of periodontitis can, reduce drug varieties, the purpose of reducing side effects.

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