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Clindamycin Hydrochloride: effects on plasma lipid profile

Number of visits:965 Date:2015/12/18 2:53:50
Clindamycin Hydrochloride: effects on plasma lipid profile and peroxidation parameters in rabbit blood plasma
Abstract: Alteration of plasma lipid profile and induction of lipid peroxidation may take place due to drug effect, which may be correlated with adverse drug reactions and drug-induced toxicity. Considering this fact, the present in vivo study was carried out to evaluate the effect of Clindamycin Hydrochloride on plasma lipid profile and per- oxidation parameters alone and in combination with ascorbic acid, a promising antioxidant. After administer- ing drug and antioxidant alone and in combination in rabbit, it was found that Clindamycin Hydrochloride had mild lipid per- oxidation induction and profile alteration capacity, which can be arrested on co-administration of ascorbic acid.
1'-(β-hydroxyethyl)-1'-demethyl Clindamycin Hydrochloride 2-acylates
1'-(β-Hydroxyethyl)-1'-demethylClindamycin Hydrochloride 2-acylate compounds of the formula: ##SPC1## Or the acid addition salts thereof wherein Halo is chlorine, bromine, or iodine, X is an acyl radical of an aliphatic carboxylic acid having from 2 to 18 carbon atoms, inclusive; R is alkyl of not more than 4 carbon atoms; and R1 is alkyl of not more than 8 carbon atoms. The compounds have Clindamycin Hydrochloride-like antibacterial activity and provide particularly high concentrations of compound in the urinary tract thereby being particularly useful in treating bacterial infections of the upper and lower urinary tract as well as L-forms in the kidney.
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clindamycin hydrochloride Separation and characterization
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