clindamycin hydrochloride

01 02 03

General content

Your present location:General content

clindamycin hydrochloride Separation and characterization

Number of visits:990 Date:2015/12/15 5:54:16
Separation and characterization of clindamycin hydrochloride and related impurities in bulk drug
A simple high-performance liquid-electrospray ionization tandem mass spectrometric (HPLC-ESI-MS n ) method has been developed for the rapid identification of clindamycin hydrochloride and its related minor impurities in bulk drug. The ESI-MS n results obtained allowed us to propose plausible schemes for their fragmentations, which were confirmed further by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS) using collision-induced dissociation (CID) method at high mass resolution. The positive ESI-MS/MS of clindamycin hydrochloride and its derivative compounds showed some diagnostic fragments, such as the neutral losses of H 2 O, HCl, methanethiol and 2-methylthio-ethenol, and the residue of 3-propyl- N -methylpyrrolidine and 3-ethyl- N -methylpyrrolidine, which are specific and useful for the identification of the lincosamide antibiotics and related impurities. According to the fragmentation mechanism of mass spectrometry and HPLC-UV-ESI-MS n data, six impurities of clindamycin hydrochloride have been identified on-line. Additionally, the positive ion mode extracted ion current (EIC) method has been used to separate and identify these lincosamide compounds.
Topical clindamycin hydrochloride 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne: a multicentre-randomized trial.
It has been shown that topical linoleic acid rich-phosphatidylcholine seems to be effective in normalization of follicular hyperkeratinization, whereas nicotinamide has an interesting anti-inflammatory effect. However, little is known about their combined effect on acne. A multicentre, double-blind, 12-week randomized vehicle and parallel-active control study was conducted by clinical and biophysical non-invasive measurements to evaluate the efficacy, tolerability and safety of a 4% nicotinamide-phospholipidic (N-PHCL) emulsion vs. 1% topical clindamycin hydrochloride phosphate applied once daily. Four percentage N-PHCL cosmetic treatment resulted slightly superior to topical clindamycin hydrochloride with all the parameters studied for its better compliance and the global clinical improvement. 08 2011 The Authors. ICS 08 2011 Society of Cosmetic Scientists and the Société Fran04aise de Cosmétologie.
Previous post:
Clindamycin Hydrochloride: effects on plasma lipid profile

Next post:
clindamycin hydrochloride-associated colitis
Welcome to our website!BACK TO HOME >>