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clindamycin hydrochloride Extractive Spectro Estimation in Bulk

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Transdermal absorption of clindamycin hydrochloride and tretinoin from topically applied anti‐acne formulations in man
The percutaneous absorption of clindamycin hydrochloride was studied in healthy male volunteers, comparing two investigative clindamycin hydrochloride (% w/v)/tretinoin (0.025% w/v) gels, containing clindamycin hydrochloride phosphate ester and clindamycin hydrochloride HCl, respectively, relative to a clindamycin hydrochloride phosphate lotion (1% clindamycin hydrochloride; Dalacin T03;). Formulations were applied daily for 5 days on the face, according to a balanced complete block design. Redness of the skin was scored visually, and blood and urine were collected. clindamycin hydrochloride plasma levels did not exceed the limit of quantification (5 ng mL611) with the clindamycin hydrochloride phosphate formulations, but one volunteer who received the clindamycin hydrochloride HCl/tretinoin gel showed plasma levels of up to 13 ng mL611. clindamycin hydrochloride urinary excretion for 12 h after application of the clindamycin hydrochloride phosphate/tretinoin gel was comparable to the values of the reference lotion, whereas the clindamycin hydrochloride HCl/tretinoin gel gave significantly higher values. Erythema appeared to be associated with increased urinary excretion. The formulations were tolerated well. In a separate clinical pilot study in acne patients, the transdermal uptake of tretinoin and clindamycin hydrochloride from the clindamycin hydrochloride phosphate/tretinoin gel was monitored. Plasma samples were collected after 4 and 12 weeks of daily treatment. None of the study plasma samples contained measurable tretinoin levels. clindamycin hydrochloride levels were not quantifiable in the majority (87%) of samples, the highest plasma level was 11 ng mL611. The chemical form of clindamycin hydrochloride proved to modulate skin irritation and percutaneous uptake of clindamycin hydrochloride from a gel formulation in healthy subjects. There was no indications for a notable transdermal uptake of tretinoin during daily application of the gel in patients, nor for an enhancing effect of tretinoin on clindamycin hydrochloride uptake. Copyright 08 1998 John Wiley & Sons, Ltd.

Extractive Spectro Estimation of Clarithromycin and clindamycin hydrochloride in Bulk and Dosage Forms

Two spectrophotometric methods are described for determination of Clarithromycin and clindamycin hydrochloride in bulk and pharmaceutical dosage forms using two acidic dyes, bromocresol purple and Bromocresol green to form ion pair extractable complexes with clarithromycin and clindamycin hydrochloride HCl then measuring absorbances at (390nm for clarithromycin or 397 nm for clindamycin hydrochloride) and 413 nm respectively. The effect,s of acidity, buffer volume and dye concentration, on the absorption were studied. Calibration curves were linear over ranges of 12–28 μg.ml-1 for Clarithromycin and 8–40 μg.ml-1 for clindamycin hydrochloride in case of bromocresol purple and of 4–20 μg.ml-1 for Clarithromycin and 16–32μg.ml-1 for clindamycin hydrochloride in case of Bromocresol green. The methods were satisfactory applied for the determination of drugs in both bulk and pharmaceutical dosage forms and results were compared statistically with reference
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clindamycin hydrochloride Percutaneous absorption in the pig and the rat.
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