clindamycin hydrochloride

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clindamycin hydrochloride History of GI Disease

Number of visits:970 Date:2015/12/14 8:17:50
clindamycin hydrochloride History of GI Disease

Use with caution in patients with a history of GI disease, particularly colitis. (See Superinfection/Clostridium difficile-associated Colitis under Cautions.)

Specific Populations

Pregnancy

Category B.

Lactation

Distributed into milk; discontinue nursing or the drug.

clindamycin hydrochloride Pediatric Use

Monitor organ system functions when used in pediatric patients (birth to 16 years of age).

Each mL of clindamycin phosphate injection contains 9.45 mg of benzyl alcohol.139 A causal relationship not established, but use of injections preserved with benzyl alcohol has been associated with toxicity in neonates.

clindamycin hydrochloride Geriatric Use

Insufficient experience in patients ≥65 years of age to determine whether they respond differently than younger adults.

Clinical experience indicates that C. difficile-associated diarrhea and colitis seen in association with anti-infectives may occur more frequently and be more severe in geriatric patients (>60 years of age).126 139 240 Geriatric patients receiving clindamycin should be carefully monitored for development of diarrhea.126 139

Hepatic Impairment

Moderate to severe liver disease may result in prolonged clindamycin half-life, but accumulation may not occur.

Periodically monitor liver enzymes in patients with severe hepatic impairment.
Common Adverse Effects

GI effects (nausea, vomiting, diarrhea, abdominal pain, tenesmus); rash; local reactions (pain, induration, sterile abscess with IM and thrombophlebitis, erythema, pain and swelling with IV).
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