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Clindamycin Hydrochloride Pharmacokinetics

Number of visits:947 Date:2015/12/14 8:12:23
Clindamycin Hydrochloride Pharmacokinetics



Approximately 90% of an oral dose of clindamycin hydrochloride rapidly absorbed from GI tract; peak serum concentration attained within 45–60 minutes. d

Prior to absorption, clindamycin palmitate hydrochloride is hydrolyzed in the GI tract to active clindamycin.d

Clindamycin palmitate oral solution and clindamycin hydrochloride capsules are bioequivalent.d

Following IM administration of clindamycin phosphate, peak serum concentrations occur within 3 hours in adults and 1 hour in children.d


Although peak plasma concentrations may be delayed, food does not have an appreciable effect on the extent of absorption of clindamycin hydrochloride capsules126 or clindamycin palmitate hydrochloride oral solution.

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