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clindamycin hydrochloride Formulation and Evaluation

Number of visits:973 Date:2015/12/9 6:06:35
Clinical Efficacy of clindamycin hydrochloride Oral Capsule against the Periodontal Disease in Dogs

Clinical Efficacy of clindamycin hydrochloride Oral Capsule against the Periodontal Disease in Dogs NAKADE Tetsuya , YOKOYAMA Shigeru , AMIMOTO Akiteru , HABATA Isao , FUJITA Keiichi , YASUDA Hidemi , HANAZAWA Toyoji , MATSUO Naoki , YAMAZAKI Tsuyoshi , YAMASHITA Tokiaki , TACHIBANA Tooru , MAETANI Shigeki , ISEKI Atsukiyo , KAWANA Tomomi , KOBAYASHI Nagisa , NAKADAI Tomomi , TAKAI Kouichi , OKUMURA Toru , WADA Naoko , SANTAKA Tadashi , FUJII Takeshi Proceedings of the Japanese Society of Antimicrobials for Animals 26, 45-51, 2004-12-28

Formulation and Evaluation of clindamycin hydrochloride – Chitosan Microspheres for Dry Powder Inhaler Formulation

The dry powder inhaler formulation of clindamycin hydrochloride microspheres was prepared for treatment of respiratory diseases. Chitosan was used as the polymer due to its compatibility with respiratory tract. The chitosan microspheres of Clindamycin HCl were prepared by spray drying method. The microspheres formed were blended with a carrier (spray dried lactose Inhalac®250). The microspheres showed the particle size in the range of 1.7-1.8 μm & spherical shape required for dpi formulation. 74% - 94% of drug was released at 120 minutes. The blend of microspheres with the carrier also showed good flow properties. Overall, spray drying is less complicated technique for the preparation of respirable.
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