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clindamycin hydrochloride Capsules in Taiwan Area

Number of visits:974 Date:2015/12/9 6:06:20
Quality Survey of clindamycin hydrochloride Capsules in Taiwan Area

In order to ensure the safety of the patients using antibiotic pharmaceuticals, this study was aimed to investigate the quality of clindamycin hydrochloride capsules in Taiwan area. Forty-nine commercial samples were collected by the local health authorities from hospitals, clinics, manufacturers and importers in different counties from January to July, 2007. Excluding the repeated lots, 44 samples were tested by analytical methods described in the USP XXIX, the Ch. P. VI and the original manufacture to evaluate their qualities. The result showed that all samples met the requirements.

Pharmacokinetics of clindamycin hydrochloride administered intravenously, intramuscularly and subcutaneously to dogs - Lavy - 2002 - Journal of Veterinary Pharmacology and Therapeutics - Wiley Online Library

The i.v. data from five of the dogs best fitted a two-compartment open-system pharmacokinetic model whereas a non-compartment model was most suitable for analysis of the data from the remaining seven dogs. The mean i.v. elimination half-life () and the mean residence time () were 124 and 143 min, respectively. The mean volume of distribution at steady state (V) was 0.86 L/kg. Little pain was recorded upon i.m. injection; mean peak serum drug concentration () was 4.4 mg/mL, the elimination half-life () was 247 min and the calculated bioavailability () was 115% of the i.v dose. Serum CPK activity was elevated to 25-fold the pretreatment level in samples collected 4, 8 and 12 h after i.m. injection. Pain was not recorded after s.c. drug administration; the mean of 20.8 mg/mL was significantly greater than the corresponding value for the i.m. route, and was 310%. The s.c. route appears to be superior to the i.m. route in terms of local tolerance and serum drug level; a 10 mg/kg SID treatment regimen is suggested for treatment of canine infections due to clindamycin sensitive bacteria.
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