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Clindamycin Hydrochloride Toxoplasmosis

Number of visits:934 Date:2015/12/7 6:19:54
Clindamycin Hydrochloride Toxoplasmosis

Treatment

Oral or IV
600 mg every 6 hours; used in conjunction with oral pyrimethamine (200-mg loading dose then 50–75 mg once daily) and oral leucovorin (10–20 mg once daily; higher dosage may be needed).

Continue acute treatment for ≥6 weeks.

Prevention of Recurrence (Secondary Prophylaxis)

Oral
300–450 mg every 6–8 hours;210 254 used in conjunction with oral pyrimethamine (25–50 mg once daily) and oral leucovorin (10–25 mg once daily).

Initiate long-term suppressive therapy or chronic maintenance therapy (secondary prophylaxis) in all patients who have completed initial treatment of toxoplasmosis encephalitis (TE).

Consideration can be given to discontinuing secondary prophylaxis in adults or adolescents who successfully completed initial treatment for TE, are asymptomatic with respect to TE, and have a sustained (≥6 months) increase in CD4+ T-cell counts to >200/mm3.

Reinitiate secondary prophylaxis if CD4+ T-cell count decreases to <200/mm3.


Clindamycin Hydrochloride Prevention of Bacterial Endocarditis

Patients Undergoing Certain Dental or Respiratory Tract Procedures

Oral
600 mg as a single dose given 30–60 minutes prior to the procedure.

IM or IV
600 mg as a single dose given 30–60 minutes prior to the procedure.

Prevention of Perinatal Group B Streptococcal Disease

Women at Risk Who Should Not Receive β-lactam Anti-infectives

IV
900 mg every 8 hours; initiate at time of labor or rupture of membranes and continue until delivery.

Perioperative Prophylaxis

Head or Neck Surgery

IV
600–900 mg given at induction of anesthesia (within 0.5–1 hour prior to incision); used with or without IV gentamicin.125 140 Additional intraoperative doses suggested every 3–6 hours for prolonged procedures (>4 hours) or if major blood loss occurs.
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