clindamycin hydrochloride

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Clindamycin hydrochloride vaginal effervescent tablet

Number of visits:1027 Date:2015/12/3 6:42:32
Comparison of two HPLC methods for determination of clindamycin hydrochloride
OBJECTIVE To improve the HPLC method for determination of clindamycin hydrochloride in Chinese Pharmacopoeia. METHODS The chromatographic parameters of clindamycin hydrochloride by HPLC method in Chinese and European Pharmacopoeia were compared. The validation of HPLC method in European Pharmacopoeia was conducted.RESULTS Compared to method in European Pharmacopoeia, the chromatogram of clindamycin could not be completely separated from the chromatograms of impurities, the chromatogram numbers of impurities were very few, and the theory plates were fast decreasing to the prescribed minimum by method in Chinese Pharmacopoeia. The validation results showed that the method in European Pharmacopoeia is simple, with acceptable sensitivity, specificity, precision and accuracy. CONCLUSION The method in European Pharmacopoeia is suitable to successfully quantify clindamycin hydrochloride. It is advised to revise the HPLC method for determination of clindamycin hydrochloride in Chinese Pharmacopoeia.
Clindamycin hydrochloride vaginal effervescent tablet and its preparing method
The effervescent clindamycin hydrochloride tablet for vagina consists of clindamycin hydrochloride as treating agent, effervescent disintegrating agent, lubricant, adhesive and surfactant. It is applied locally to generate fine and lasting foam with homogeneously distributed medicine component with increased contact area between medicine and vaginal mucous membrane for full absorption. The administration via vagina has no first pass effect of liver, no systemic negative effect, lowered toxicity, raised effective concentration of medicine in the disease focus, high curative effect and other advantages.
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