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clindamycin hydrochloride capsules in healthy volunteers

Number of visits:1082 Date:2015/12/1 6:57:22
Dissolution of Different Brands of Clindamycin Hydrochloride Capsules

Objective:The dissolution of different brands of Clindamycin Hydrochloride Capsules in different PH dissolution mediums was discussed.Methods:According to the second dissolution method in ChP,with the 50r/min rotate speed and different dissolution mediums of 900 ml,the dissolution curves were drawn.Results:The results showed that the dissolution of five brands of Clindamycin Hydrochloride Capsules in four different mediums (water,PH1.2 hydrochloric acid,PH4.0 phosphate buffer and PH6.8 phosphate buffer)had significant difference. Conclusions:The inner quality of Clindamycin Hydrochloride Capsules should be improved.

Relative bioavailability of clindamycin phosphate ester tablets and clindamycin hydrochloride capsules in healthy volunteers

Objective To determine the relative bioavailability of clindamycin phosphate ester tablets and clindamycin hydrochloride capsules.Methods According to the randomized crossover design,each healthy male volunteer was given a single oral dose of clindamycin phosphate ester tablets and clindamycin capsules.The plasma concentrations of clindamycin were obtained and determined by HPLC-UV.Results The pharmacokinetic parameters of orally disintegrating clindamycin tables and capsules in the plasma were as follows:AUC0-10 was (10.9±1.2) and (11.2±1.2)mg·h·L-1,Cmax was (3.7±0.6) and (3.7±0.6) mg·L-1;tmaxwas (0.83±0.09) and (0.83±0.10)h,and t1/2 was (2.0±0.1) and (2.1±0.1) h.The relative bioavailability of the two preparations was (97.8±5.4) %.Conclusion The two preparations are bioequivalent.
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