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clindamycin hydrochloride injection Side effects

Number of visits:996 Date:2015/12/1 6:55:46
Side effects of the clindamycin hydrochloride injection

Objective:To explore the adverse effects of clindamycin hydrochloride injection,and provide reference for clinical rational drug use.Methods:From June 2006 to June 2008 used clindamycin hydrochloride injection treatment of 120 cases of infection and inflammation in patients with clinical data were analyzed retrospectively,summarized the num ber and type adverse reactions.Results:In this group,15 cases had adverse reactions,which mainly 12.5% for gastrointestinal reaction and allergic reaction and local pain.Conclusion:Taking seriously of adverse reactions of clindamycin hydrochloride injection can reduce the damage of patients,ensure the rationality of the drug.

Validation of Microbial Limit Test for Compound Clindamycin Hydrochloride Gel

OBJECTIVE:To establish microbial limit test for Compound clindamycin hydrochloride gel and to carry out the validation of three methods.METHODS:According to the appendices volumeⅡof Chinese Pharmacopeia(edition 2005),microbial limit test which contained routine test,medium dilution method and membrane-filter method was adopted to validate Compound clindamycin hydrochloride gel.Recoveries of three methods were compared to make sure the suitable validation method.RESULTS:In routine test,recovery of trial bacteria was lower than 70%and controlled bacteria couldn't be found out.In medium di-lution method,recovery of trial bacteria was higher than 70%and still lower than the recovery of diluents.In membrane-filter method,recovery of trial bacteria was higher than 90%,and controlled bacteria grew well.Membrane-filter method could eliminate inhibition effect of Compound clindamycin hydrochloride gel on bacteria.CONCLUSION:Membrane-filter method is effective and practical for microbial limit test of Compound clindamycin hydrochloride gel.
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