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Clindamycin Hydrochloride Injection Partial safety

Number of visits:1060 Date:2015/11/30 7:20:27
Investigation and analysis of Clindamycin Hydrochloride Capsules in vitro dissolution

Objective Through comparing 4 different manufacturers of Clindamycin Hydrochloride Capsules in vitro solubility,provides the reference for the clinical rational drug use. Methods Refer to the relevant literature,the 2010 edi- tion of Chinese Pharmacopoeia two appendix solubility first method,dissolved quantity of each sample was determined at dif- ferent time by high performance liquid chromatography,and the solubility parameter to the Weibull equation,and analyzing the results of the test. Results According to the dissolution parameters T 50 and T d,clindamycin hydrochloride capsules from different manufacturers in different dissolution have some differences in behavior dissolving medium. Conclusion The dissolution rate of the drug associated with it's pH environment,in the clinical course of medication should be noted.

Partial safety test of Clindamycin Hydrochloride Injection

Objective To evaluate the safety of Clindamycin Hydrochloride Injection.Methods The ear edge vein vessel irritation test,muscle irritation test,guinea pig active systemic allergic test and the rat passive cutaneous anaphylaxis test,hemolysis test were adopted for study.Results Clindamycin Hydrochloride Injection had no obvious vessel stimulation at the site of administration by intravenous drip,but caused muscle stimulation.Guinea pig active systemic allergic reaction and rat passive cutaneous anaphylaxis reaction were negative.No hemolysis of rabbit red blood cells and the agglutination reaction were observed.Conclusion Clindamycin Hydrochloride Injection used by intravenous drip is safe.Intramuscular injection may cause local tissue irritation.
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