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Clindamycin Hydrochloride Reconstitution

Number of visits:1215 Date:2015/11/27 7:18:47
Clindamycin Hydrochloride Reconstitution

Reconstitute clindamycin palmitate hydrochloride oral solution by adding 75 mL of water to the 100-mL bottle. A large portion of the water should be added initially and the

bottle shaken vigorously; the remainder of the water should then be added and the bottle shaken until the solution is uniform.121 The resulting solution contains 75 mg of

clindamycin/5 mL.

Clindamycin Hydrochloride IV Infusion

Clindamycin Hydrochloride Dilution

Prior to IV infusion, clindamycin phosphate injections (including ADD-Vantage vials) must be diluted with a compatible IV solution to a concentration ≤18 mg/mL.139 (See Rate of

Administration under Dosage and Administration.)

The clindamycin phosphate pharmacy bulk package is not intended for direct IV infusion;139 doses of the drug from the bulk package must be further diluted in a compatible IV

infusion solution prior to administration.139 The bulk package is intended for use only under a laminar flow hood.139 Entry into the vial should be made using a sterile transfer

set or other sterile dispensing device, and the contents dispensed in aliquots using appropriate technique; multiple entries with a syringe and needle are not recommended

because of the increased risk of microbial and particulate contamination.139 After entry into the bulk package vial, the entire contents should be used promptly and any unused

portion discarded within 24 hours after initial entry.

The commercially available clindamycin phosphate injections in 5% dextrose should not be used in series connections with other plastic containers, since such use could result in

air embolism from residual air being drawn from the primary container before administration of fluid from the secondary container is complete.
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