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Clindamycin Hydrochloride Uses for Prevention of Perinatal Group B Streptococcal Disease

Number of visits:1252 Date:2015/11/27 7:17:47
Clindamycin Hydrochloride Uses for Prevention of Perinatal Group B Streptococcal Disease

Alternative to penicillin G or ampicillin for prevention of perinatal group B streptococcal (GBS) disease? in penicillin-allergic pregnant women at risk for anaphylaxis with a

β-lactam anti-infective.

Intrapartum anti-infective prophylaxis to prevent early-onset neonatal GBS disease is administered to women identified as GBS carriers during routine prenatal GBS screening

performed at 35–37 weeks during the current pregnancy and to women who have GBS bacteriuria during the current pregnancy, a previous infant with invasive GBS disease, unknown

GBS status with delivery at <37 weeks gestation, amniotic membrane rupture for ≥18 hours, or intrapartum temperature of ≥38°C.

Penicillin G is the regimen of choice and ampicillin is the preferred alternative. Cefazolin can be used in penicillin-allergic women who do not have immediate-type penicillin

hypersensitivity, but clindamycin or erythromycin should be used in penicillin-allergic women at high risk for anaphylaxis.

Consider that S. agalactiae (group B streptococci) with in vitro resistance to clindamycin and erythromycin has been reported with increasing frequency; perform in vitro

susceptibility tests of clinical isolates obtained during GBS prenatal screening. GBS resistant to erythromycin often are resistant to clindamycin, although this may not be

evident in results of in vitro testing. If in vitro susceptibility testing is not possible, results are unknown, or isolates are found to be resistant to erythromycin or

clindamycin, vancomycin is recommended for intrapartum prophylaxis in penicillin-allergic women at high risk for anaphylaxis with β-lactams.
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