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Clindamycin Hydrochloride Uses for Pneumocystis jiroveci Pneumonia

Number of visits:1478 Date:2015/11/27 7:16:02
Clindamycin Hydrochloride Uses for Pneumocystis jiroveci (Pneumocystis carinii) Pneumonia

Treatment of Pneumocystis jiroveci (formerly Pneumocystis carinii) pneumonia(PCP); used in conjunction with primaquine.Designated an orphan drug by FDA for use in this condition.

Co-trimoxazole is initial drug of choice for treatment in most adults, adolescents, and children, including HIV-infected patients; a regimen of clindamycin and primaquine is an alternative for adults and adolescents with mild to moderately severe PCP who have had an inadequate response to co-trimoxazole or when co-trimoxazole is contraindicated or not tolerated.

Clindamycin in conjunction with primaquine has been used as an alternative for long-term suppressive or chronic maintenance therapy (secondary prophylaxis) of PCP?, but USPHS/IDSA states the regimen should only be considered for primary or secondary prophylaxis of PCP in unusual situations when the usually recommended agents (co-trimoxazole, dapsone, dapsone with pyrimethamine and leucovorin, aerosolized pentamidine, atovaquone) cannot be used.

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