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clindamycin hydrochloride supplier:Spectrophotometric and titrimetric determination of clindamycin hydrochloride in pharmaceutical preparations

Number of visits:994 Date:2016/4/6 14:48:55
Two simple and accurate methods are described for the determination of clindamycin hydrochloride. The spectrophotometric method involves the oxidation of the sulfur atom in this drug with potassium iodate in acidic medium with the liberation of iodine and subsequent extraction with cyclohexane followed by measuring the absorbance at 520 nm. The titrimetric method involves direct titration of the drug with N-bromosuccinimide. The relative standard deviation for both methods was less than 1%. The proposed methods were applied to the determination of the drug in pure and capsule forms.
Clinical Experience With Clindamycin Hydrochloride: I. Treatment of Streptococcal and Mixed Streptococcal-Staphylococcal Skin Infections
Two hundred and forty-four children were evaluated in a study comparing clindamycin hydrochloride, erythromycin, and phenoxymethyl penicillin for the treatment of streptococcal pyoderma. Similar numbers of patients were followed during (day 7) and after (day 14) therapy in each of the three treatment groups. All patients had skin lesions positive for group A streptococci with or without staphylococci; the percentage rate of pure and mixed cultures was similar for the three groups of patients. Both clindamycin and erythromycin proved somewhat superior to penicillin on the basis of effecting earlier clinical cures and sterilization of skin lesions. Streptococcal eradication rates by day 7 were as follows: clindamycin, 97%; erythromycin, 99%; and penicillin, 91%. By day 14, clinical and bacteriologic cure rates were essentially the same in each group: clindamycin, 99%; erythromycin, 99%; and penicillin, 97%. Persistence or reacquisition of a pyoderma strain in the upper respiratory tract was highest in that group treated with penicillin. There were no adyerse reactions associated with clindamycin or the other antibiotic agents evaluated. However, clindamycin holds no advantage over erythromycin for treatment of streptococcal pyoderma, and additional clinical information will be required to determine whether the potential for toxicity in children will compromise the use of this newer antibiotic.
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