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The preparation of clindamycin hydrochloride liposome phosphate

Number of visits:1129 Date:2016/2/23 5:56:39
The preparation of clindamycin hydrochloride liposome phosphate
The purpose of preparation of clindamycin hydrochloride liposome phosphate And measure the envelopment rate and particle size. Evaporation method using ultrasonic method clindamycin hydrochloride liposome phosphate, high performance liquid chromatography (HPLC) method to detect clindamycin hydrochloride phosphate coating rate, the average particle size is measured by laser particle size instrument. Results with the orthogonal design method, the optimization of the preparation of liposomes and prescription for: lecithin: cholesterol is 5:1, the ultrasonic time of 6 min, evaporation temperature of 35 ℃, phospholipids: clindamycin hydrochloride is 5:3, phospholipids, trehalose is 2:1. Clindamycin hydrochloride phosphate in 5.0 ~ 50 mu g/mL, insider sex is good. Three groups of clindamycin hydrochloride liposome phosphate coating rate were 52.26%, 50.13% and 53.75%, respectively. Conclusion clindamycin hydrochloride phosphate liposome preparation technology is feasible and the quality control method is simple and accurate.

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HPLC method for determination of clindamycin hydrochloride phosphate and its related substances of methodological research

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Daughter of department of gynaecology piece of joint clindamycin hydrochloride phosphate treatment of chronic pelvic inflammatory disease
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