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Clindamycin Hydrochloride in mucous type of pseudomonas aeruginosa biofilm

Number of visits:907 Date:2016/2/22 9:29:47
Objective to explore the Clindamycin Hydrochloride on mucous type of pseudomonas aeruginosa (PA) of bacterial biofilm in vitro. Methods experiment divided into normal saline control group, individual with Clindamycin Hydrochloride (CM) group, individual with levofloxacin (LFX) group and CM + LFX. In a test tube double dilution method to determine the minimum inhibitory concentration (MIC); Biofilm in vitro model set up by using the plate method; With methyl thiazole blue four nitrogen (determined by MTT) live bacteria counting method determination of live bacteria number; Scanning electron microscopy (SEM) observation of Clindamycin Hydrochloride or levofloxacin separate function and two kinds of medicines to the destruction of the biofilm and scavenging effect. The PA training after 7 days can form stable biofilm. Clindamycin Hydrochloride or levofloxacin role alone, bacterial biofilm morphology and survival number no change. After the joint application, the biofilm structure destruction, live bacteria quantity significantly reduced. Conclusion CM and LFX type of mucus PA biofilm have synergistic inhibition effect.
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