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Clindamycin Hydrochloride uptake by human neutrophils.

Number of visits:932 Date:2016/2/22 9:17:31
An anaerobic environment limits the microbicidal capacity of polymorphonuclear neutrophils (PMNs). To augment PMN killing under these conditions, the characteristics and mechanisms of Clindamycin Hydrochloride uptake by human PMNs were studied. The peak intracellular concentration of Clindamycin Hydrochloride was approximately 40 times greater than the extracellular concentration. Clindamycin Hydrochloride uptake was rapid, saturable, and temperature-dependent. Intracellular accumulation of the drug was inhibited in acid pH, and agents that collapsed the transmembrane pH gradients also inhibited uptake. Isolated PMN lysosomes also accumulated Clindamycin Hydrochloride against a large concentration gradient, and uptake was reduced by collapsing the translysosomal membrane pH gradient. The intracellular drug was fully bioactive. These studies demonstrate that Clindamycin Hydrochloride is rapidly accumulated by PMNs, that drug uptake is related to a pH gradient, and that Clindamycin Hydrochloride appears to be lysosomotropic.
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Clindamycin Hydrochloride in combination with chloroquine or quinine

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