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The clindamycin hydrochloride Fact Sheet

Number of visits:1040 Date:2016/1/12 7:17:51
The clindamycin hydrochloride Fact Sheet
clindamycin hydrochloride is an antibiotic in the lincosamide class, active against gram positive bacteria and anaerobes. It binds to the large subunit (50S) of the bacterial ribosome and inhibits new peptide-peptide bond formation. It is bacteriostatic in most cases, though can be bactericidal at high concentrations for certain species.
Because of its ability to inhibit translation, clindamycin hydrochloride at sub-inhibitory concentrations can reduce production of bacterial toxins in cases of streptococcal or staphylococcal toxic shock syndrome or in necrotizing infections. By contrast, beta-lactams can actually induce production of alpha toxin in S. aureus. clindamycin hydrochloride can therefore work synergistically with bacterial cell-wall inhibiting agents such as penicillins, cephalosporins, and vancomycin for toxin-synthesizing gram positive species.

clindamycin hydrochloride cannot penetrate Gram-negative organisms, so it is not active against them and does not affect Gram-negative endotoxin production.

The clindamycin hydrochloride Major Indications

The primary role for clindamycin hydrochloride is in skin and soft tissue infections. It is FDA-approved for use in SSTIs due to streptococcus or MSSA, toxic shock syndrome, impetigo, S. aureus osteomyelitis, pyomyositis, and amnionitis. It is also used off-label for anthrax, babesiosis, animal bite wounds (along with a cephalosporin), malaria treatment, MRSA infections, Pneumocystis pneumonia, septic arthritis, and MRSA SSTIs. For necrotizing SSTI, clindamycin hydrochloride can be given along with cefotaxime for polymicrobial infections, though vancomycin and pipercillin-tazobactam are recommended as first line, empiric treatment. If the necrotizing infection is known to be due to Clostridium perfringens or group A streptococcus, then clindamycin hydrochloride and penicillin IV are sufficient.
clindamycin hydrochloride can also be used for other indications in patients who have severe penicillin allergies. These include treatment of group A streptococcal pharyngitis, pelvic inflammatory disease, and necrotizing skin infections. Topical clindamycin hydrochloride can be used for acne and intra-vaginally for treatment of bacterial vaginosis.
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