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Clindamycin Hydrochloride CapsulesⅡ

Number of visits:990 Date:2015/12/25 2:29:40

Adverse reactions of the clindamycin hydrochloride capsules.

(1) gastrointestinal reaction: include nausea, vomiting, abdominal pain, diarrhea; Severe cases with abdominal cramps, abdominal tenderness, severe diarrhea (water or purulent blood samples), associated with fever, abnormal thirst and fatigue (false membranous enteritis). Diarrhea, enteritis, and false membranous enteritis can appear on the treatment or after discontinuation of treatment.

(2) allergic reaction: usually with mild to moderate measles rash most, followed by skin rash and hives blister samples, occasional multiform erythema, exfoliative dermatitis, part performance for Stevens Johnson syndrome.

(3) may appear abnormal liver function, renal function is unusual, occasional neutropenia and eosinophil increase, etc.


Interaction:

(1) clindamycin hydrochloride can enhance the neuromuscular blocking phenomenon of the inhalation anesthetics, paralysis of skeletal 

muscle weakness and respiratory depression or (apnea), with it should be noted in operation or after. With anticholinesterase drugs or calcium salt treatment is effective.

(2) clindamycin hydrochloride are used with anti-creep antidiarrheal, containing argil antidiarrheal: clindamycin in the course of treatment, even a few weeks after treatment has caused severe watery diarrhoea of pseudo membranous enteritis.Because it can make delay in colon endotoxin eduction, causing diarrhea prolong and intensify, therefore, anti-creep antidiarrheal shoulds not be with clindamycin hydrochloride. Argil antidiarrheal and clindamycin oral at the same time, the absorption of the latter will be significantly reduced, hence they should not be taken at the same time, must be interval of time (at least 2 hours).

(3) clindamycin hydrochloride capsules the effects of neuromuscular blocking, muscle weakness and taking the drugs when pooling will lead to the weakening of the effects of skeletal muscle. To control the symptoms of myasthenia gravis, resistance to muscle weakness during the share of the treatment drug dosage should be adjusted.

(4) the chloramphenicol or erythromycin on targeted replacement of this product, or obstruct the latter with the combination of bacterial ribosomal 50s subunits in vitro tests show this product with erythromycin antagonism effect, therefore, this product is unfavorable and chloramphenicol or erythromycin share.

(5) opioid share, the product of respiratory inhibition and opioid central respiratory inhibition can be lengthened by accumulative  phenomenon has lead to respiratory depression or cause respiratory paralysis (apnea) may, therefore, must to closely observe the patient or guardian

(6) clindamycin hydrochloride capsules can enhance the effect of neuromuscular blockers, both share should be avoided.


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