clindamycin hydrochloride

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Product Name:

clindamycin hydrochloride

Number:
CAS NO:
21462-39-5
Assay:
Appearance:
white crystalline powder
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6901
Product Details

What is clindamycin hydrochloride Oral Liquid Antibiotic?

clindamycin hydrochloride Oral Liquid Antibiotic is an antibiotic used to treat soft tissue infections, dental infections, and bone infections caused by susceptible strains of bacteria. clindamycin hydrochloride Oral Liquid Antibiotic requires a prescription from your veterinarian.

For: Cats and Dogs
Benefits:
• Effectively remedies bacterial infections
• Treats soft tissue infections
• Treats bone and dental infections
How it works:
clindamycin hydrochloride Oral Liquid Antibiotic fights various kinds of bacterial infections. It’s an antibiotic, administered in liquid form, which works by stopping the growth of bacteria.

Cautions:
Antibiotics can cause diarrhea. If the diarrhea is watery or has blood in it, call your veterinarian. Do not use any medication to stop the diarrhea unless instructed by your veterinarian.

More Information:
Brand Name
Antirobe (Pharmacia and Upjohn), Antirobe Aquadrops (Pharmacia and Upjohn), Cleocin (Pharmacia)
Generic Name
clindamycin hydrochloride
What is the most important information I should know about clindamycin hydrochloride: Do not use this medication if your pet is allergic to clindamycin hydrochloride or lincomycin (Bactramycin, L-Mycin, Lincocin). Do not give clindamycin hydrochloride together with erythromycin (E-Mycin, E.E.S., Ery-Tab, and others). Tell your veterinarian if your pet has kidney disease, liver disease, colitis, asthma, eczema, or allergic skin reaction. Give this medication for the entire length of time prescribed by your veterinarian. Symptoms may get better before the infection is fully treated. Antibiotics can cause diarrhea. If the diarrhea is watery or has blood in it, call your veterinarian. Do not use any medication to stop the diarrhea unless your veterinarian has told you to do so. Periodic blood testing will be necessary. Kidney and liver function may also need to be tested. Prior to any surgery on the pet, let the veterinarian know if the pet is still taking clindamycin hydrochloride. clindamycin hydrochloride is FDA-approved for use in dogs only; however, it is a commonly accepted practice for veterinarians to use clindamycin hydrochloride in cats. clindamycin hydrochloride is a prescription medication available as 25mg and 150mg capsules and 25mg/ml liquid drops.

What is clindamycin hydrochloride: clindamycin hydrochloride is an antibiotic that fights bacterial infections in the body. It is used to treat serious infections. clindamycin hydrochloride may also be used for purposes other than those listed in this guide.

What should I discuss with my veterinarian before giving clindamycin hydrochloride to my pet: Do not use this medication if your pet isallergic to clindamycin hydrochloride or lincomycin (Bactramycin, L-Mycin, Lincocin). Do not give clindamycin hydrochloride together with erythromycin (E-Mycin, E.E.S., Ery-Tab, and others). Tell your veterinarian if your pet has kidney disease, liver disease, colitis, asthma, eczema, or allergic skin reaction. Tell your veterinarian if your pet is pregnant or lactating.

How should this medication be given: Give this medication exactly as prescribed by your veterinarian. Do not give in larger amounts, or give for longer than recommended by your veterinarian. Follow the directions on the prescription label. Allow plenty of water for your pet to drink. Give this medication for the entire length of time prescribed by your veterinarian. Symptoms may get better before the infection is fully treated. Periodic blood testing will be necessary. Kidney and liver function may also need to be tested. Prior to any surgery on your pet, let your veterinarian know if your pet is still taking clindamycin hydrochloride. Store clindamycin hydrochloride at room temperature away from moisture and heat.

What happens if I miss giving a dose: Give the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and give the next regularly scheduled dose. Do not give a double dose of the medication.

What happens if I overdose the pet: Seek emergency veterinary medical attention if you think you have given your pet too much of this medication. Symptoms of clindamycin hydrochloride overdose may include vomiting, loss of appetite, weight loss, depression, behavior changes, or seizure.

What should I avoid while giving clindamycin hydrochloride to my pet: Antibiotics can cause diarrhea. If the diarrhea is watery or has blood in it, call your veterinarian. Do not use any medication to stop the diarrhea unless your veterinarian has told you to do so.

What are the possible side effects of clindamycin hydrochloride: If any of the following serious side effects occur, stop giving clindamycin hydrochloride and seek emergency veterinary medical help: an allergic reaction (hives; difficulty breathing; or swelling of the face, lips, tongue, or throat). Stop the medication and talk to your veterinarian if any of these side effects occur: diarrhea that is watery or bloody; fever; chills; body aches; nausea; stomach pain; loss of appetite; dark urine; jaundice; urinating less than usual or not at all; fever; headache; or blistering, or peeling of the skin. Side effects other than those listed in this guide may occur. Talk to your veterinarian about any side effect that is unusual or especially bothersome to your pet.

What other drugs will affect clindamycin hydrochloride: There may be other drugs that can affect clindamycin hydrochloride. Tell your veterinarian about all prescription and over-the-counter medications you give your pet including vitamins, minerals, and herbal products.

Where can I get more information: Your pharmacist has information written for health professionals that you can read.

clindamycin hydrochloride Molecular Structure:


clindamycin hydrochloride

Formula
C18H33ClN2O5S.HC
Molecular Weight
461.44
Synonyms
7(S)-Chloro-7-deoxylincomycin hyddrochloride;L-threo-a-D-galacto-Octopyranoside, methyl7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-,hydrochloride (1:1);7-Chloro-7-deoxylincomycin hydrochloride;Antirobe vet
EINECS
244-398-6
Melting Point
141 °C
Boiling Point
647 °C at 760 mmHg
Flash Point
345.1 °C
Solubility:water
50 mg/mL, clear, colorless
Appearance
white crystalline powder
Risk Codes
36/37/38
Safety
26-36-37/39
InChI
InChI=1/C18H33ClN2O5S.ClH/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25);1H/t9?,10-,11+,12?,13+,14-,15-,16-,18-;/m0./s1

Clindamycin Hydrochloride Oral Drops intruduction
This page contains information on Clindamycin Hydrochloride Oral Drops for veterinary use.
The information provided typically includes the following:
Clindamycin Hydrochloride Oral Drops Indications
Warnings and cautions for Clindamycin Hydrochloride Oral Drops
Direction and dosage information for Clindamycin Hydrochloride Oral Drops
Clindamycin Hydrochloride Oral Drops Caution
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
Clindamycin Hydrochloride Oral Drops Description
Clindamycin Hydrochloride Oral Drops (clindamycin hydrochloride liquid) contains clindamycin hydrochloride which is the hydrated salt of clindamycin. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chlorosubstitution of the 7(R)-hydroxyl group of a naturally produced antibiotic produced by Streptomyces lincolnensis var. lincolnensis.
Clindamycin Hydrochloride Oral Drops (For Use in Dogs and Cats) is a palatable formulation intended for oral administration. Each mL of Clindamycin Hydrochloride Oral Drops contains clindamycin hydrochloride equivalent to 25 mg clindamycin; and ethyl alcohol, 8.64%.
Clindamycin Hydrochloride Oral Drops Indications
Clindamycin Hydrochloride Oral Drops (for use in dogs and cats) is indicated for the treatment of infectionscaused by susceptible strains of the designated microorganisms in the specific conditions listed below:
Dogs: Skin infections (wounds and abscesses) due to coagulase positive staphylococci (Staphylococcus aureus or Staphylococcus intermedius). Deep wounds and abscesses due to Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens. Dental infections due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens. Osteomyelitis due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens.
Cats: Skin infections (wounds and abscesses) due to Staphylococcus aureus, Staphylococcus intermedius and Streptococcus spp. Deep wounds and infections due to Clostridium perfringens and Bacteroides fragilis. Dental infections due to Staphylococcus aureus, Staphylococcus intermedius, Streptococcus spp., Clostridium perfringens and Bacteroides fragilis.
Clindamycin Hydrochloride Oral Drops Dosage And Administration
Clindamycin Hydrochloride Oral Drops Dogs:
Infected Wounds, Abscesses And Dental Infections
Clindamycin Hydrochloride Oral Drops Oral: 2.5 - 15.0 mg/lb body weight every 12 hours.
Duration: Treatment with Clindamycin Hydrochloride Oral Drops products may be continued up to a maximum of 28 days if clinical judgment indicates. Treatment of acute infections should not be continued for more than three or four days if no response to therapy is seen.
Clindamycin Hydrochloride Oral Drops Dosage Schedule:
Clindamycin Hydrochloride Oral Drops Liquid
Clindamycin Hydrochloride Oral Drops, administer 1-6 mL/10 lbs body weight every 12 hours.
Clindamycin Hydrochloride Oral Drops Dogs:
Clindamycin Hydrochloride Oral Drops Osteomyelitis
Oral: 5.0-15.0 mg/lb body weight every 12 hours.
Duration: Treatment with Clindamycin Hydrochloride Oral Drops is recommended for a minimum of 28 days. Treatment should not be continued for longer than 28 days if no response to therapy is seen.
Clindamycin Hydrochloride Oral Drops Dosage Schedule:
Clindamycin Hydrochloride Oral Drops Liquid
Clindamycin Hydrochloride Oral Drops, administer 2-6 mL/10 lbs body weight every 12 hours.
Clindamycin Hydrochloride Oral Drops Cats:
Infected Wounds, Abscesses And Dental Infections
5.0 - 15.0 mg/lb body weight once every 24 hours depending on the severity of the condition.
Duration: Treatment with Clindamycin Hydrochloride Oral Drops may be continued up to a maximum of 14 days if clinical judgment indicates. Treatment of acute infections should not be continued for more than three to four days if no clinical response to therapy is seen.
Clindamycin Hydrochloride Oral Drops Dosage Schedule:
Clindamycin Hydrochloride Oral Drops, to provide 5.0 mg/lb, administer 1 mL/5 lbs body weight once every 24 hours; to provide 15.0 mg/lb, administer 3 mL/5 lbs body weight once every 24 hours.
Clindamycin Hydrochloride Oral Drops Contraindications
Clindamycin Hydrochloride Oral Drops is contraindicated in animals with a history of hypersensitivity to preparations containing clindamycin or lincomycin.
Because of potential adverse gastrointestinal effects, do not administer to rabbits, hamsters, guinea pigs, horses, chinchillas or ruminating animals.
Human Warnings
Keep out of reach of children. Not for human use.
Clindamycin Hydrochloride Oral Drops Precautions
During prolonged therapy of one month or greater, periodic liver and kidney function tests and blood counts should be performed.
The use of Clindamycin Hydrochloride Oral Drops occasionally results in overgrowth of non-susceptible organisms such as clostridia and yeasts. Therefore, the administration of Clindamycin Hydrochloride Oral Drops should be avoided in those species sensitive to the gastrointestinal effects of clindamycin (see CONTRAINDICATIONS). Should superinfections occur, appropriate measures should be taken as indicated by the clinical situation.
Patients with very severe renal disease and/or very severe hepatic disease accompanied by severe metabolic aberrations should be dosed with caution, and serum clindamycin levels monitored during high-dose therapy.
Clindamycin hydrochloride has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, Clindamycin Hydrochloride Oral Drops should be used with caution in animals receiving such agents.
Safety in gestating bitches and queens or breeding male dogs and cats has not been established.
Clindamycin Hydrochloride Oral Drops Pharmacology
Absorption: Clindamycin hydrochloride is rapidly absorbed from the canine and feline gastrointestinal tract.
Dog Serum Levels: Serum levels at or above 0.5 µg/mL can be maintained by oral dosing at a rate of 5.0 mg/lb of clindamycin hydrochloride every 12 hours. This same study revealed that average peak serum concentrations of clindamycin occur 1 hour and 15 minutes after oral dosing. The elimination half-life for clindamycin in dog serum was approximately 5 hours. There was no bioactivity accumulation after a regimen of multiple oral doses in healthy dogs.
Clindamycin Serum Concentrations 2.5 mg/lb (5.5 mg/kg) After B.I.D. Oral Dose of clindamycin hydrochloride to Dogs
Cat Serum Levels: Serum levels at or above 0.5 µg/mL can be maintained by oral dosing at a rate of 5.0 mg/lb of clindamycin hydrochloride every 24 hours. The average peak serum concentration of clindamycin occurs approximately 1 hour after oral dosing. The elimination half-life of clindamycin in feline serum is approximately 7.5 hours. In healthy cats, minimal accumulation occurs after multiple oral doses of clindamycin hydrochloride, and steady-state should be achieved by the third dose.
Clindamycin Serum Concentrations 5 mg/lb (11 mg/kg) After Single Oral Dose of clindamycin hydrochloride to Cats
Clindamycin Hydrochloride Oral Drops Metabolism And Excretion
Extensive studies of the metabolism and excretion of clindamycin hydrochloride administered orally in animals and humans have shown that unchanged drug and bioactive and bioinactive metabolites are excreted in urine and feces. Almost all of the bioactivity detected in serum after Clindamycin Hydrochloride Oral Drops product administration is due to the parent molecule (clindamycin). Urine bioactivity, however, reflects a mixture of clindamycin and active metabolites, especially N-demethyl clindamycin and clindamycin sulfoxide.
Clindamycin Hydrochloride Oral Drops Animal Safety Summary
Rat and Dog Data: One year oral toxicity studies in rats and dogs at doses of 30, 100 and 300 mg/kg/day (13.6, 45.5 and 136.4 mg/lb/day) have shown clindamycin hydrochloride to be well tolerated. Differences did not occur in the parameters evaluated to assess toxicity when comparing groups of treated animals with contemporary controls. Rats administered clindamycin hydrochloride at 600 mg/kg/day (272.7 mg/lb/day) for six months tolerated the drug well; however, dogs orally dosed at 600 mg/kg/day (272.7 mg/lb/day) vomited, had anorexia, and subsequently lost weight. At necropsy these dogs had erosive gastritis and focal areas of necrosis of the mucosa of the gallbladder.
Safety in gestating bitches or breeding males has not been established.
Cat Data: The recommended daily therapeutic dose range for clindamycin hydrochloride (Clindamycin Hydrochloride Oral Drops) is 11 to 33 mg/kg/day (5 to 15 mg/lb/day) depending on the severity of the condition. Clindamycin hydrochloride (Clindamycin Hydrochloride Oral Drops) was tolerated with little evidence of toxicity in domestic shorthair cats when administered orally at 10x the minimum recommended therapeutic daily dose (11 mg/kg; 5 mg/lb) for 15 days, and at doses up to 5x the minimum recommended therapeutic dose for 42 days.
Gastrointestinal tract upset (soft feces to diarrhea) occurred in control and treated cats with emesis occurring at doses 3x or greater than the minimum recommended therapeutic dose (11 mg/kg/day; 5 mg/lb/day). Lymphocytic inflammation of the gallbladder was noted in a greater number of treated cats at the 110 mg/kg/day (50 mg/lb/day) dose level than for control cats. No other effects were noted. Safety in gestating queens or breeding male cats has not been established.
Clindamycin Hydrochloride Oral Drops How Supplied
Clindamycin Hydrochloride Oral Drops is available as 20 mL filled in 30 mL bottles (25 mg/mL) supplied in packers containing 12 cartoned bottles with direction labels and calibrated dosing droppers.
Clindamycin Hydrochloride Uses
Clindamycin Hydrochloride Uses for Acute Otitis Media (AOM)
Alternative for treatment of AOM? known or presumed to be caused by penicillin-resistant Streptococcus pneumoniae.
Not a first-line agent, but AAP and AAFP state clindamycin may be considered in individuals with penicillin hypersensitivity who may have AOM caused by penicillin-resistant S. p
Use of clindamycin also may be considered if AOM persists after treatment with amoxicillin and clavulanate or ceftriaxone and tympanocentesis is not available to make a
bacteriologic diagnosis.
Clindamycin Hydrochloride Uses for Bone and Joint Infections
Treatment of serious bone and joint infections (including acute hematogenous osteomyelitis) caused by susceptible Staphylococcus aureus.
Adjunct in the surgical treatment of chronic bone and joint infections caused by susceptible bacteria.
Clindamycin Hydrochloride Uses for Gynecologic Infections
Treatment of serious gynecologic infections (e.g., endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, postsurgical vaginal cuff infection) caused by susceptible anaerobes.
Treatment of pelvic inflammatory disease (PID); used in conjunction with other anti-infectives.124 128 257 When a parenteral regimen is indicated for treatment of PID, IV
clindamycin in conjunction with an IV or IM aminoglycoside (e.g., gentamicin) is one of the recommended regimens.
Clindamycin Hydrochloride Uses for Intra-abdominal Infections
Treatment of serious intra-abdominal infections (e.g., peritonitis, intra-abdominal abscess) caused by susceptible anaerobes.
Clindamycin Hydrochloride Uses for Respiratory Tract Infections
Treatment of serious respiratory tract infections (e.g., pneumonia, empyema, lung abscess) caused by susceptible anaerobes, S. pneumoniae, other streptococci, or S. aureus.
A drug of choice for treatment of community-acquired pneumonia (including aspiration pneumonia) when anaerobes are identified or suspected.
Clindamycin Hydrochloride Uses for Septicemia
Treatment of serious septicemia caused by susceptible anaerobes, streptococci, or S. aureus.
Clindamycin Hydrochloride Uses for Skin and Skin Structure Infections
Treatment of serious skin and skin structure infections caused by susceptible anaerobes, S. pyogenes, other streptococci, or staphylococci.
Clindamycin Hydrochloride Uses for Actinomycosis
Treatment of actinomycosis? caused by Actinomyces israelii;120 144 follow-up treatment (6–12 months) after initial parenteral treatment (4–6 weeks) with penicillin G or ampicillin.
clindamycin hydrochloride capsules in dogs
Oral bioavailability and pharmacokinetic behaviour of clindamycin in dogs was investigated following intravenous (IV) and oral (capsules) administration of clindamycin hydrochloride, at the dose of 11 mg/kg BW. The absorption after oral administration was fast, with a mean absorption time (MAT) of 0.87+/-0.40 h, and bioavailability was 72.55+/-9.86%. Total clearance (CL) of clindamycin was low, after both IV and oral administration (0.503+/-0.095 vs. 0.458+/-0.087 L/h/kg). Volume of distribution at steady-state (IV) was 2.48+/-0.48 L/kg, indicating a wide distribution of clindamycin in body fluids and tissues. Elimination half-lives were similar for both routes of administration (4.37+/-1.20 h for IV, vs. 4.37+/-0.73 h for oral). Serum clindamycin concentrations following administration of capsules remained above the MICs of very susceptible microorganisms (0.04-0.5 microg/mL) for 12 or 10 h, respectively. Time above the mean inhibitory concentration (MIC) is considered as the index predicting the efficacy of clindamycin (T(>MIC) must be at least 40-50% of the dosing interval), so a once-daily oral administration of 11 mg/kg BW of clindamycin can be considered therapeutically effective. For less susceptible bacteria (with MICs of 0.5-2 microg/mL) the same dose should be given but twice daily.
Efficacy of clindamycin hydrochloride in refractory periodontitis. 12-month results
The purpose of this study was to evaluate the use of clindamycin hydrochloride as an adjunct to conventional periodontal therapy in the treatment of patients who had previously been unsuccessfully treated with scaling, periodontal surgery and the use of tetracycline. Thirteen patients with a history of "refractory" periodontitis were thoroughly scaled and monitored by repeated attachment level measurements for the presence of active destructive periodontitis. Disease activity was defined as a 3-mm loss in attachment from baseline measurements or the occurrence of a periodontal abscess. When active disease was detected, each patient was scaled again and placed on clindamycin hydrochloride 150 mg qid for 7 days. Following the adjunctive use of clindamycin in combination with scaling, the incidence of gingival sites demonstrating active disease in the group of 13 patients decreased from an annual rate of 10.7 to 0.5%. Each patient demonstrated a decreased incidence of active sites per unit of time. Clinical parameters such as probing depth, gingival redness, bleeding on probing and suppuration showed dramatic improvement at 12 months after clindamycin therapy. The percentage of pockets with probing depths greater than 6 mm, 4 to 6 mm and 1 to 3 mm changed from 11 to 2%, 38 to 24% and 51 to 74% respectively, following clindamycin therapy as compared to scaling alone. The percentage of sites bleeding on probing decreased from 33% after scaling alone to 8% following clindamycin and scaling. Gingival redness decreased from 36 to 1% of sites. Suppuration also decreased from 8% of buccal or lingual surfaces after scaling alone to 1% of surfaces following scaling and clindamycin.(ABSTRACT TRUNCATED AT 250 WORDS)
clindamycin hydrochloride is the generic equivalent to Antirobe. This is an antibiotic the treats soft tissue, dental, and bone infections caused by susceptible strains of bacteria plus certain protozoa.
Clindamycin Hydrochloride Antibiotic

What is clindamycin hydrochloride? This is a lincosamide class of antibiotics that is given by mouth (orally). It is effective in the treatment of susceptible bacterial infections. It can also treat some protozoal infections.

What are the benefits of clindamycin hydrochloride?
Generic equivalent to Antirobe.
Works well to treat susceptible bacterial infections including dental infections.
Also treats some protozoal infections.
Minimal side effects when used as directed.

Formulated for: dogs, cats, and ferrets can be given clindamycin hydrochloride.
How is this medication given? Follow your veterinarians precise instructions regarding the use of clindamycin hydrochloride.
This is an oral medication (given by mouth). Always complete the entire course of prescribed medication or the infection may recur or worsen.
Give directly by mouth followed by some water or with a small amount of food.
How does this medication work?clindamycin hydrochloride prevents vulnerable bacteria from producing proteins that are essential to their growth so bacteria can no longer grow.
What results can I expect clindamycin hydrochloride is absorbed quickly through the digestive tract and can travel to multiple organs.
Susceptible bacterial/protozoal infections should be killed and your pet should start to feel better if clindamycin hydrochloride is used as directed.
Infections may recur or worsen if the entire course of medication is not completed.
What form(s) does clindamycin hydrochloride come in? clindamycin hydrochloride HCl is available as a capsule, tablet, and liquid.
Generic Name: clindamycin hydrochloride(Common Drug Name
Common Brand Name: Antirobe
Dose and Administration: Use according to your veterinarians exact directions.
Give some water when given directly by mouth . You can also give each dose of medication in a small amount of food. Make sure your pet has unlimited access to water.
Complete the entire course of medication even if your pet starts feeling better or infection can return or worsen.
Only give this medication to the pet it has been prescribed for. If you miss a dose, give it as soon as you remember. If you miss a dose and it is close to the next dose, skip the previous dose and continue the course of medication on schedule.
Uses: clindamycin hydrochloride is an antibiotic that is used to treat susceptible soft tissue, dental, bone, and some protozoal infections.
Possible Side Effects: GI side effects such as vomiting, diarrhea, bloody diarrhea, and inappetance have been reported.
Some pets may experience an allergic reaction which can cause hives, itching, swelling, or other symptoms.
Call your veterinarian at once if your pet is acting strange in any way after taking Antirobe.
Drug and Food Interactions: Interactions may occur with erythromycin or cyclosporine. Other interactions may occur so always tell your vet about any other medications/supplements your pet is taking prior to giving clindamycin hydrochloride.
Precautions: Do not give clindamycin hydrochloride to pets who are allergic to it or similar antibiotics.
No safety studies have been conducted in pregnant or lactating females.
clindamycin hydrochloride should not be given to horses, guinea pigs, rabbits, chinchillas, hamsters, or ruminants.
Pets with kidney or liver disease may need dose adjustments so use clindamycin hydrochloride cautiously in these patients.
Storage:Store at room temperature away from children and pets.
A prescription from your veterinarian is required to purchase clindamycin hydrochloride.

Before taking this medicine

You should not use this medicine if you are allergic to clindamycin hydrochloride or lincomycin.
To make sure clindamycin hydrochloride is safe for you, tell your doctor if you have:
a history of colitis, Crohn's disease, or other intestinal disorder;
a history of eczema, or allergic skin reaction;
liver disease;
asthma, or a history of severe allergic reaction to aspirin;
if you also take erythromycin; or
if you are allergic to yellow food dye.
FDA pregnancy category B. clindamycin hydrochloride is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
clindamycin hydrochloride can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
Do not give a clindamycin hydrochloride injection to a child without medical advice. The injectable medicine contains an ingredient that can cause serious side effects or death in very young infants or premature babies. Do not allow an older child to use this medicine without supervision of an adult.

How should I use clindamycin hydrochloride?
Take clindamycin hydrochloride exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Take the capsule with a full glass of water to keep it from irritating your throat.
Measure the oral liquid with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
clindamycin hydrochloride is sometimes given as an injection into a muscle, or injected into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Use a disposable needle only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
To make sure this medicine is not causing harmful effects, you may need frequent medical tests during treatment.
Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. clindamycin hydrochloride will not treat a viral infection such as the flu or a common cold.
Store at room temperature away from moisture and heat. Protect the injectable medicine from high heat.
Do not store the oral liquid in the refrigerator. Throw away any unused oral liquid after 2 weeks.

What should I avoid while using clindamycin hydrochloride?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop using clindamycin hydrochloride and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
What other drugs will affect clindamycin hydrochloride?
Other drugs may interact with clindamycin hydrochloride, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.



Clindamycin hydrochloride release.it treatment of acute type limited wisdom tooth pericoronitis randomized controlled study

Of local application of clindamycin hydrochloride medicine membrane treatment of acute type limited wisdom tooth pericoronitis results of clinical observation and bacteriological tests, to evaluate its wisdom tooth pericoronitis treatment of meaning. Method: to use clindamycin hydrochloride as main raw materials, developed for matrix gelatin into pericoronitis, wash with regular import of traditional treatments for iodine glycerin randomized controlled clinical trials, 4 d bacteriology examination after the treatment respectively. Results: release.it statistical processing group and the control group by the chi-square test results (P < 0.01), clindamycin hydrochloride release.it treatment group is better than the control group. Conclusion: show that clindamycin hydrochloride release.it treatment of mixed infection of wisdom tooth pericoronitis has its unique role.
1% clindamycin hydrochloride cream acne treatment
1% clindamycin hydrochloride emulsion (terri fairy lotion) American upjohn pharmaceutical factory production of water-soluble emulsion containing fat and alcohol. External use is not coloring, especially for dry and sensitive skin acne patients. In 1996 3 ~ 6 month we use this drug of pharmaceutical preparation in hospital and 5% benzoyl peroxide gel (control group) compare treatment of 32 patients with acne and 29 cases respectively, are reported as follows. One, the clinical data of patients randomly divided into 2 groups, are medium degree of acne, except polymerized and cystic acne. Within 2 weeks is not used in the treatment of acne and drugs for external use only, except of the pregnancy. Treatment group 32 cases, including 9 cases of male and female 23 cases,
With clindamycin hydrochloride curing chloroquine resistant malaria
September 4, 1992 in Gabon Lambarene a hospital outpatient service meet the following conditions of 90 cases of malaria patients were collected for study: (1) of plasmodium falciparum infection; (2) asexual protozoa disease acuity 200 / mu l; (3) the entire tracking observer 48 h after parasite remove internal energy; (4) confirmed by urine nearly 7 days without chloroquine and quinine and sulfanilamide treatment; 5. Older than 15 years old; 6. Non pregnant women; All landowners volunteered for the tests. The 90 patients were randomly divided into two groups. A group of 48 cases of the first dose of 10 mg/kg chloroquine matrix, 24 h and 48 h after respectively take 10 mg/kg and 5 mg/kg. Another group of 42 cases, once every 12 h suit clindamycin hydrochloride, clindamycin matrix 5 mg/kg, 10 times in a row. Record every 12 h clinical signs and symptoms until the symptoms disappear
Amide cephalosporins (Aztreonam) and clindamycin phosphate mixed hydrochloride injection stability
Beta lactam antibiotics amide rhzomorph Aztreonam (hereinafter referred to as A) oral invalid, often to match it into 10 or 20 mg/ml ampoule for use. Experiment: will the sterilization booster injection (Ⅰ) and clindamycin phosphate hydrochloride injection (150 mg/ml) (Ⅱ), with 0.9% sodium chloride injection or 5% glucose injection as a diluent, mixture made with injection, two drug concentration respectively: 20 mg/ml (Ⅰ) + 6 mg/ml (Ⅱ); 20 mg/ml (Ⅰ) + 3 mg/ml (Ⅱ); 10 mg/ml (Ⅰ) + 6 mg/ml (Ⅱ); 10 mg/ml (Ⅰ) + 3 mg/ml (Ⅱ). Seven days and 22 ~ 23 ℃ under 4 ℃ (room temperature) 48 h, within A certain time interval, the sampling observation samples crystallization, and HPLC method, in 205 nm wavelength ultraviolet detection A
Gastrointestinal side effects of clindamycin hydrochloride - 1000 consecutive cases analysis
Clindamycin hydrochloride for lincomycin - chlorine - 7 July to oxygen derivatives. The advantages of the former is: in the gastrointestinal tract absorption is better and is not affected by food, the minimum bacteriostasis concentration lower species of bacteria and its antibacterial spectrum includes a variety of anaerobic bacteria and certain parasite. But since its discovery in 1973 clindamycin hydrochloride can cause false membrane colitis, and January 1975 340 cases report, including 85 deaths, 20 periods within membrane colitis is the main factor of death.
Clindamycin hydrochloride related colitis
This article report confirmed by microscopic examination of the rectum and colon biopsy and clindamycin hydrochloride on the pseudo membrane colitis 47 cases, aged 15 to 87, of which 13 cases (28%) of the original disease as: cancer in 5 cases, 4 cases of diabetes, amyotrophic lateral sclerosis, leukemia, rheumatoid arthritis, chronic renal failure in 1 case. Drug use way: 31 cases of oral, 8 cases of intravenous administration of intramuscular injection in 1 case, 7 cases of a variety of ways. 11 cases (23%) with other antibiotics (14 cases of cephalothin, 9 cases of gentamicin and ampicillin in 2 cases, 1 case) benzoic different oxazole penicillin, 6 cases of them are in diarrhea or with 1 ~ 2 agent clindamycin hydrochloride after use, 35 cases (74%), with clindamycin hydrochloride, the other used clindamycin in 1 case and clindamycin hydrochloride. After onset of: except 1 case begins with a bloody diarrhoea, yu on the onset of the watery diarrhoea; 33 patients with spastic abdominal pain,

ead all of this leaflet carefully before you start taking this medicine.
Keep this leaflet. You may need to read it again.
If you have further questions, please ask your doctor or pharmacist.
This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
In this leaflet:
What clindamycin hydrochloride Capsules are and what they are used for
Before you take clindamycin hydrochloride Capsules
How to take clindamycin hydrochloride Capsules
Possible side effects
How to store clindamycin hydrochloride Capsules
Further information
1. What clindamycin hydrochloride Capsules are and what they are used for
clindamycin hydrochloride is an antibiotic. clindamycin hydrochloride Capsules are used to treat infections caused by certain types of bacteria only. In particular, the types of bacteria that cause infections of the skin, of the flesh immediately under the skin, of the bones, and bacteria that are often found in abscesses and in infections of the abdomen (belly) are sometimes treated with clindamycin hydrochloride.

2. Before you take clindamycin hydrochloride Capsules
Do not take clindamycin hydrochloride Capsules:

If you or your child have or have ever had an allergic reaction to any medicines that contain clindamycin hydrochloride or another very similar antibiotic called lincomycin .
If you or your child have or have ever had an allergic reaction to any other ingredients in clindamycin hydrochloride Capsules (see section 6 Further information).
If you or your child have diarrhoea.
Take special care with clindamycin hydrochloride Capsules:

If you or your child have asthma, hay fever or eczema
If you or your child have kidney or liver problems
If you or your child have ever had inflammation of the large bowel (called colitis) with severe blood-stained diarrhoea in the past
If you or your child have ever had any other serious illness of the stomach or gut or bowels in the past
clindamycin hydrochloride does not get into the brain and is therefore not suitable for treating serious infections in and around the brain. Your doctor may need to give you another antibiotic if you have these infections.

Taking other medicines

Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

You can take clindamycin hydrochloride with some antibiotics, but you should not take clindamycin hydrochloride if you are already taking a type of antibiotic called a macrolide (such as erythromycin, clarithromycin, azithromycin, or telithromycin) or streptogramin. Discuss this with your doctor if you are not sure.

If you go into hospital or attend a dentist for treatment, it is important to tell the doctor or dentist that you are taking clindamycin hydrochloride Capsules as they may change the way some hospital medicines work. In particular, clindamycin hydrochloride can increase the effects of some medicines that are used in general anaesthetics (muscle relaxants).

If you are taking medicines for a condition called myasthenia gravis, clindamycin hydrochloride could stop them working as well as usual.

clindamycin hydrochloride like other antibacterials may interfere with Oral Typhoid vaccine. To avoid this, clindamycin hydrochloride should not be taken 3 days before and after taking the Oral Typhoid vaccine. Discuss this with your doctor if you are not sure.

As with almost all antibiotics, clindamycin hydrochloride may interfere with the contraceptive pill. If you are taking the pill, use extra contraception such as condoms or a diaphragm whilst you are taking clindamycin hydrochloride Capsules and for at least seven days afterwards. If in doubt, ask your doctor for advice.

Pregnancy and Breast-feeding

clindamycin hydrochloride is not usually given to pregnant women unless it is really necessary. Your doctor will advise you if you really need to take clindamycin hydrochloride while you are pregnant. If possible, you should stop breast-feeding while you are taking clindamycin hydrochloride. If you cannot stop breast-feeding, you should take care to look at your baby s stools. If your baby gets diarrhoea, with or without blood in it, or shows any other signs of illness, tell your doctor immediately. You should stop breast-feeding if this happens.

Driving and using machines

Taking clindamycin hydrochloride is not likely to interfere with driving or operating machinery.

Important information about some of the ingredients in clindamycin hydrochloride Capsules

This medicine contains lactose. If you have been told by your doctor that you are intolerant to some sugars, ask your doctor for advice before taking this medicine.

3. How to take clindamycin hydrochloride Capsules
Always take your capsules as prescribed by your doctor. Please read the pharmacy label and ask your doctor or pharmacist if you have any questions before starting to take clindamycin hydrochloride.

You can take the capsules with or without food. You should:

swallow the capsules whole
wash them down with a full glass of water
space the doses evenly through the day
The daily dose depends on your illness. Your doctor will tell you how many capsules you should take and this will also appear on the pharmacy label on the pack. Follow the instructions carefully. Never change the dose your doctor has prescribed.

Adults and elderly patients:

The recommended dose in adults and the elderly is from 150 mg up to a maximum of 450 mg (one to three capsules) every six hours, depending on the severity of the infection.

Children:

These capsules are not suitable for children who are too young to be able to take them whole. For children who can swallow capsules, the recommended dose is between 3 and 6 mg per kg every six hours, depending on the severity of the infection. Your doctor will work out the right dose for your child s weight.

You should make sure that you take the capsules for the number of days that your doctor has told you to take them.

Long term use of clindamycin hydrochloride Capsules:

If you have to take clindamycin hydrochloride Capsules for a long time, your doctor may arrange regular liver, kidney and blood tests. Do not miss these check-ups with your doctor.

Long term use can also make you more likely to get other infections that do not respond to clindamycin hydrochloride treatment.

If you take more clindamycin hydrochloride Capsules than you should:

If you take too many capsules, you should tell your doctor at once.

If you cannot speak to your doctor, go to the accident and emergency department in the nearest hospital. Remember to take the clindamycin hydrochloride Capsules pack with you so they will know exactly what you have taken. Do not take any more clindamycin hydrochloride Capsules until your doctor tells you to.

If you forget to take clindamycin hydrochloride Capsules:

If the forgotten dose is just a few hours late, take it straight away. If it is nearly time for your next dose miss out the forgotten one. Do not take a double dose to make up for a missed dose.

If you stop taking clindamycin hydrochloride Capsules:

You should not stop taking the capsules before the end of the course just because you feel better because your infection may come back again or even get worse. You should only stop taking your capsules before finishing the course if your doctor tells you to.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

4. Possible side effects
Like all medicines clindamycin hydrochloride Capsules can cause side effects although not everybody gets them.

Tell your doctor immediately if you develop:

severe, persistent or bloody diarrhoea (which may be associated with stomach pain or fever). This is an uncommon side effect which may occur during or after completing treatment with antibiotics and can be a sign of serious bowel inflammation.
signs of a severe allergic reaction such as sudden wheeziness, difficulty in breathing, swelling of eyelids, face or lips, rash or itching (especially affecting the whole body).
blistering and peeling of large areas of skin, fever, cough, feeling unwell and swelling of the gums, tongue or lips.
yellowing of the skin and whites of the eyes (jaundice).
Other possible side effects may include:

Effects on your nervous system:
- impaired sense of taste

Effects on your skin:
- reddening of the skin, skin rash, itching (hives)

Effects on your stomach and intestines:
- throat ulcers, sore throat, feeling sick, being sick, stomach pain and diarrhoea

Effects on your blood system:
- reduced numbers of blood cells which may cause bruising or bleeding or weaken the immune system
- an increase in the number of blood cells called eosinophils. Some people who have this also have breathing problems

Effects on your liver:
- poor liver function

Effects on your genital area:
- inflammation of the vagina.

Effects on your musculoskeletal system:
- widespread joint pains.

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

5. How to store clindamycin hydrochloride Capsules
Keep out the sight and reach of children.

Do not take your medicine after the expiry date on the label which is stated on the carton. The expiry date refers to the last day of that month. Return any expired or unused capsules to your pharmacist.

Do not store above 25 C. Store in the original package.

Do not use clindamycin hydrochloride Capsules if you notice any visible signs of deterioration such as a change in the colour.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6. Further information
What clindamycin hydrochloride Capsules contains: The active ingredient is clindamycin hydrochloride hydrochloride.

Each capsule contains clindamycin hydrochloride hydrochloride equivalent to 150 mg of clindamycin hydrochloride.

The other ingredients are lactose monohydrate, maize starch, magnesium stearate, talc. Capsule shell: Gelatin, azorubine (E122) and indigo carmine (E132). Printing ink: Shellac, titanium dioxide (E171), propylene glycol (E1520).

What clindamycin hydrochloride Capsules looks like and contents of the pack:

clindamycin hydrochloride 150 mg Capsules are lavender/maroon and are marked CL150. clindamycin hydrochloride Capsules are available in cartons containing 24 capsules and containers of 100 capsules.

clindamycin hydrochloride images


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clindamycin hydrochloride images

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